Spence was initially a taught-on-the-job high-street photographer in the 1960s. From there she began a journey towards independent-thinking and non-commercial photographic work that developed out of a growing political consciousness reflected in her use of documentary and then collaborative and politically-charged practices. Spence used the image as a means to both empower and educate, exemplified by her involvement with such pioneering photographic collectives such as The Faces and the Hackney Flashers, the latter of whom engaged with issues of female labor and childcare in the London Borough of Hackney (at the time a socially marginalized neighborhood.)

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